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Mesenchymal Stem Cells

Mesenchymal Umbilical Stem Cells

How Do They Work?

Wharton’s Jelly Derived Mesenchymal Stem Cells (MSCs)

The umbilical cords utilized by our affiliated cell expansion partners are certified ethically sourced umbilical cords obtained from consenting adult birth mothers who are between the ages of 18 and 25 and who have been monitored closely during their pregnancy and have undergone extensive testing.  Both birth parents of the umbilical cord donor have had their medical history properly evaluated, verified, and vetted to ensure no medical history of cancer, Alzheimer’s, other neurological diseases, autism spectrum disorder nor any associated risk factors. All children from whom the umbilical cord was obtained were successfully delivered during full-term cesarian section birth in a certified hospital. The Wharton’s Jelly-derived umbilical cord-derived Mesenchymal stem cells utilized by Trinity Stem Cells are early passage multipotent progenitor cells derived from human umbilical cord Wharton’s Jelly that is capable of supporting hematopoiesis and differentiating into multiple lineages (osteogenic, adipogenic, chondrogenic, neurogenic, myogenic, and cardiomyogenic.)

Why Use MSCs

Mesenchymal stem cells (MSCs) are advantageous over other stem cells types for a variety of reasons. First, they avoid the ethical issues that surround embryonic stem cell research.

Second, Repeated studies have found MSCs to be immune-privileged, which makes them an advantageous cell type for allogeneic transplantation. MSCs reduce both the risks of rejection and complications of transplantation.

Third, there have been advances in the use of umbilical cord mesenchymal stem cells to regenerate human tissues, including cartilage, meniscus, tendons, and bone fractures, because MSCs can exert regenerative effects through homing to sites of damage, paracrine signalling, regulating immune responses, and positively affecting the microenvironment.

MSC Culture Images

MSCs in Culture: Day 13
MSCs in Culture: Day 22
MSCs in Culture: Day 28

Keeping Mesenchymal Stem Cells Young

During culture, MSCs are expanded in numbers to reach a therapeutically beneficial dose. However, every time a stem cell divides (self-renews) it loses some of its abilities. In a way each time a cell divides it ages, becoming slower and less able to perform its specialist tasks. At Trinity Stem Cell Treatment Center, we utilize only 2 grades of UCMSCs – Premium: Passage 1 Mesenchymal Stem Cells (P1 MSCs) (with higher rates of efficiency) and 3 Mesenchymal Stem Cells (P3 MSCs).

Mechanism’s for Functional Deterioration of Stem Cells in Aging

Full term birth, ethically sourced, Wharton’s Jelly umbilical derived MSCs avoid the ethical issues of embryonic stem cells.
Role as Regulatory Cells
MSCs synthesize and secrete a variety of macromolecules that are known regulators of hematopoietic and other regenerative cells.
Ease of Growth in Culture
Advanced knowledge and expertise is utilized by our affiliated laboratory providers in growing MSCs in culture, including protocols for isolation, expansion, and differentiation.

Favorable Immune Status:

MSCs lack the co-stimulatory molecules of the B7 family that are required to initiate an immune response. This allows the administration of MSC preparations across immune system MHC barriers (Major Histocompatibility Complex) without concern for immunological rejection or the need for immunosuppression. This makes Wharton’s Jelly umbilical derived Mesenchymal stem cells a universal stem cell source, which does not require blood or tissue typing to be received safely.

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